I would suggest that as long as the patient continues on their LAIA and is stable from a psychosis perspective it would be safe to restart the Vyvanse. Start low, go slow, continue to monitor for any evidence of psychotic symptoms. Also key to ensure no substances (cannabis included!). Avoid caffeine. Encourage adequate sleep and good sleep hygiene with consistent sleep/wake schedule. I would invite a parent or significant other to be involved in “objective monitoring” for any concerning shifts from baseline. Ask the patient to monitor for “warning signs” of relapse to psychosis.